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Korean J Physiol Pharmacol 2017 Sep; 21(5): 457-464
Turgut Yapanoglu1, Fatih Ozkaya2, Ali Haydar Yilmaz3, Renad Mammadov4, Ferda Keskin Cimen5, Erkan Hirik6, and Durdu Altuner4,*
Effect of etoricoxib on experimental oxidative testicular ischemia–reperfusion damage in rats induced with torsion–detorsion
1Department of Urology, Faculty of Medicine, Ataturk University, Erzurum 25240, 2Department of Urology, Bayburt State Hospital, Bayburt 69010, 3Department of Urology, Bilecik State Hospital, Bilecik 11100, 4Department of Pharmacology, Faculty of Medicine, Erzincan University, Erzincan 24100, 5Department of Pathology, Mengucek Gazi Education and Research Hospital, Erzincan 24100, 6Department of Urology, Faculty of Medicine, Erzincan University, Erzincan 24100, Turkey
Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720o degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion.
Keyword : Etoricoxib, Gene expression, Ischemia-reperfusion, Torsion-detorsion