Journal of Neurogastroenterology and Motility
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Korean J Physiol Pharmacol 2018 Jan; 22(1): 101-110
Sun Ae Hwang, Chi Dae Kim, and Won Suk Lee*
Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice
Department of Pharmacology, Pusan National University School of Medicine, Yangsan 50612, Korea
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5 mg/kg, i.p.) twice 1 and 6 h after ischemic insult. CAPE significantly reduced the infarct size as well as the expression of tumor necrosis factor-α, hypoxia-inducible factor-1α, monocyte chemoattractant protein-1, interleukin-1α, and in-doleamine 2,3-dioxygenase in the cerebral cortex ipsilateral to the photothrombosis. Moreover, it induced an increase in heme oxygenase-1 immunoreactivity and interleukin-10 expression. These results suggest that CAPE exerts a remarkable neuroprotective effect on ischemic brain injury via its anti-inflammatory properties, thereby providing a benefit to the therapy of cerebral infarction.
Keyword : Caffeic acid phenethyl ester, Cerebral ischemia, Chemokine, Cytokine, Neuroinflammation